aflatoxin biosynthetic process

Term ID

GO:0045122

Synonyms

aflatoxin anabolism
aflatoxin biosynthesis
aflatoxin formation
aflatoxin synthesis

Definition

The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. (3)

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: aflatoxin B synthase activity averantin hydroxylase activity

aflatoxin B synthase activity averantin hydroxylase activity Show first 5 Terms
is a type of: acetate metabolic process aflatoxin metabolic process mycotoxin biosynthetic process organic heteropentacyclic compound biosynthetic process

acetate metabolic process aflatoxin metabolic process mycotoxin biosynthetic process organic heteropentacyclic compound biosynthetic process Show first 5 Terms
has_part: 5'-hydroxyaverantin dehydrogenase activity averantin hydroxylase activity demethylsterigmatocystin 6-O-methyltransferase activity norsolorinate anthrone synthase activity norsolorinic acid ketoreductase activity ... Show All 10 Terms

5'-hydroxyaverantin dehydrogenase activity averantin hydroxylase activity demethylsterigmatocystin 6-O-methyltransferase activity norsolorinate anthrone synthase activity norsolorinic acid ketoreductase activity sterigmatocystin 7-O-methyltransferase activity versicolorin B desaturase activity versicolorin B synthase activity versicolorin reductase activity versiconal hemiacetal acetate esterase activity Show first 5 Terms
negatively regulated by: negative regulation of aflatoxin biosynthetic process

negative regulation of aflatoxin biosynthetic process Show first 5 Terms
positively regulated by: positive regulation of aflatoxin biosynthetic process

positive regulation of aflatoxin biosynthetic process Show first 5 Terms
regulated by: regulation of aflatoxin biosynthetic process

regulation of aflatoxin biosynthetic process Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations