double-strand break repair via synthesis-dependent strand annealing

Term ID

GO:0045003

Synonyms

mitotic gene conversion
SDSA

Definition

SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. 10357855

References

Reactome:R-HSA-5693554

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing DNA recombinase assembly heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing meiotic strand displacement involved in double-strand break repair via SDSA

DNA double-strand break processing involved in repair via synthesis-dependent strand annealing DNA recombinase assembly heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing meiotic strand displacement involved in double-strand break repair via SDSA Show first 5 Terms
is a type of: double-strand break repair via homologous recombination

double-strand break repair via homologous recombination Show first 5 Terms

Phenotype

Phenotype caused by Genes