phosphatidylinositol 3-kinase/protein kinase B signal transduction

Term ID

GO:0043491

Synonyms

• AKT signal transduction
• AKT signaling
• AKT signaling cascade
• AKT signalling cascade
• phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction
• PI3K-PKB/Akt pathway
• PI3K/Akt signal transduction
• PI3K/PKB signal transduction
• PKB signal transduction
• PKB signaling
• PKB signaling cascade
• PKB signalling cascade
• protein kinase B signal transduction
• protein kinase B signaling
• protein kinase B signaling cascade
• protein kinase B signalling cascade

Definition

An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. (2)

References

• Reactome:R-HSA-198203
• Reactome:R-HSA-198323
• Reactome:R-HSA-198693

Ontology

GO: Biological Process    QuickGO    AmiGO