proteasome-mediated ubiquitin-dependent protein catabolic process

Term ID

GO:0043161

Synonyms

proteasomal pathway
proteasomal processing
proteasomal ubiquitin-dependent protein breakdown
proteasomal ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-dependent protein catabolism
proteasomal ubiquitin-dependent protein degradation
proteasome pathway

Definition

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

References

Reactome:R-HSA-75815

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: proteasomal protein catabolic process ubiquitin-dependent protein catabolic process

proteasomal protein catabolic process ubiquitin-dependent protein catabolic process Show first 5 Terms
has subtype: anaphase-promoting complex-dependent catabolic process cytoplasm protein quality control by the ubiquitin-proteasome system mitochondria-associated ubiquitin-dependent protein catabolic process negative regulation of transcription by transcription factor catabolism nuclear protein quality control by the ubiquitin-proteasome system ... Show All 10 Terms

anaphase-promoting complex-dependent catabolic process cytoplasm protein quality control by the ubiquitin-proteasome system mitochondria-associated ubiquitin-dependent protein catabolic process negative regulation of transcription by transcription factor catabolism nuclear protein quality control by the ubiquitin-proteasome system ribosome-associated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process stress-induced homeostatically regulated protein degradation pathway ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ubiquitin-dependent protein catabolic process via the N-end rule pathway Show first 5 Terms
inverse has_part: endoplasmic reticulum stress-induced pre-emptive quality control

endoplasmic reticulum stress-induced pre-emptive quality control Show first 5 Terms
negatively regulated by: negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal ubiquitin-dependent protein catabolic process Show first 5 Terms
positively regulated by: positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process Show first 5 Terms
regulated by: regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal ubiquitin-dependent protein catabolic process Show first 5 Terms

Phenotype

Phenotype caused by Genes