symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity

Term ID

GO:0039574

Synonyms

• disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity
• suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity
• suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity
• suppression by virus of host TYK2 activity

Definition

A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits. (2)

References

• VZ:720

Ontology

GO: Biological Process    QuickGO    AmiGO