symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity

Term ID

GO:0039557

Synonyms

• inhibition of host interferon regulatory factor-7 by virus
• inhibition of host IRF7 by virus
• suppression by virus of host interferon regulatory factor 7 activity
• suppression by virus of host IRF7 activity
• suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity

Definition

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. (3)

References

• VZ:653

Ontology

GO: Biological Process    QuickGO    AmiGO