MDA-5 signaling pathway

Term ID

GO:0039530

Synonyms

• IFIH1 signaling pathway
• MDA-5 signalling pathway
• MDA5 signaling pathway
• melanoma differentiation-associated gene 5 signaling pathway

Definition

The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. (2)

References

Ontology

GO: Biological Process    QuickGO    AmiGO