ERBB2 signaling pathway

Term ID

GO:0038128

Synonyms

• ERBB2 signalling pathway
• HER2 signaling pathway
• NEU signaling
• receptor tyrosine-protein kinase erbB-2 signaling pathway

Definition

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 16460914

References

• Reactome:R-HSA-1227986

Ontology

GO: Biological Process    QuickGO    AmiGO