ATF6-mediated unfolded protein response

Term ID

GO:0036500

Synonyms

• activating transcription factor 6 signaling in unfolded protein response
• ATF6 branch of UPR
• ATF6 signal transduction pathway
• ATF6 signaling in response to endoplasmic reticulum stress
• ATF6-alpha UPR branch
• ATF6-beta UPR branch
• endoplasmic reticulum unfolded protein response; ATF6 signaling
• UPR signaling by ATF6 stress sensor

Definition

The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. 22013210

References

• Reactome:R-HSA-381033

Ontology

GO: Biological Process    QuickGO    AmiGO