IRE1-mediated unfolded protein response

Term ID

GO:0036498

Synonyms

• endoplasmic reticulum unfolded protein response; IRE1 signaling
• ERN1-mediated unfolded protein response
• inositol-requiring enzyme 1-mediated unfolded protein response
• inositol-requiring transmembrane kinase/endonuclease signal transduction
• IRE1 branch of UPR
• IRE1 signal transduction pathway
• IRE1 signaling in response to endoplasmic reticulum stress
• IRE1alpha unfolded protein response
• IRE1p unfolded protein response
• UPR signaling by IRE1 stress sensor

Definition

The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 22013210

References

• Reactome:R-HSA-381070

Ontology

GO: Biological Process    QuickGO    AmiGO