hippo signaling

Term ID

GO:0035329

Synonyms

• hippo signal transduction
• hippo signaling cascade
• hippo signaling pathway
• hippo signalling cascade
• Salvador-Warts-Hippo signaling pathway
• SWH pathway

Definition

An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. (3)

References

Ontology

GO: Biological Process    QuickGO    AmiGO