VCP-NPL4-UFD1 AAA ATPase complex

Term ID

GO:0034098

Synonyms

• Cdc48p-Npl4p-Ufd1p AAA ATPase complex
• p97-Ufd1-Npl4 complex

Definition

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO