Mis6-Sim4 complex

Term ID

GO:0031511

Synonyms

• Mcm21
• Mis6 centromere subcomplex
• Mis6-Mal2-Sim4 centromere complex
• Sim4 complex

Definition

A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO