death-inducing signaling complex

Term ID

GO:0031264

Synonyms

• death receptor-induced signaling complex
• death receptor-induced signalling complex
• death-inducing signalling complex
• DISC
• DISC protein complex

Definition

A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (3)

References

• Wikipedia:Death-inducing_signaling_complex

Ontology

GO: Cellular Component    QuickGO    AmiGO