regulatory ncRNA-mediated gene silencing

Term ID

GO:0031047

Synonyms

gene silencing by RNA
RNA-dependent gene silencing
RNA-mediated gene silencing

Definition

A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. 15020054

References

Reactome:R-HSA-211000

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: regulatory ncRNA processing RISC complex assembly

regulatory ncRNA processing RISC complex assembly Show first 5 Terms
is a type of: negative regulation of gene expression

negative regulation of gene expression Show first 5 Terms
has subtype: co-transcriptional gene silencing by RNA interference machinery regulatory ncRNA-mediated heterochromatin formation regulatory ncRNA-mediated post-transcriptional gene silencing

co-transcriptional gene silencing by RNA interference machinery regulatory ncRNA-mediated heterochromatin formation regulatory ncRNA-mediated post-transcriptional gene silencing Show first 5 Terms
negatively regulated by: negative regulation of gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA Show first 5 Terms
regulated by: regulation of gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA Show first 5 Terms

Phenotype

Phenotype caused by Genes