lipoate synthase activity

Term ID

GO:0016992

Synonyms

• LipA
• lipoic acid synthase
• lipoyl synthase activity
• LS
• protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
• protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity

Definition

Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin].

References

• EC:2.8.1.8
• MetaCyc:RXN-14950
• MetaCyc:RXN-14957
• MetaCyc:RXN-14959
• MetaCyc:RXN0-949
• RHEA:16585
• Reactome:R-HSA-6793591

Ontology

GO: Molecular Function    QuickGO    AmiGO