RISC complex

Term ID

GO:0016442

Synonyms

• micro-ribonucleoprotein complex
• miRNP complex
• RNA-induced silencing complex

Definition

A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. (2)

References

• Wikipedia:RNA-induced_silencing_complex

Ontology

GO: Cellular Component    QuickGO    AmiGO