heparan sulfate proteoglycan biosynthetic process

Term ID

GO:0015012

Synonyms

• heparan sulfate proteoglycan anabolism
• heparan sulfate proteoglycan biosynthesis
• heparan sulfate proteoglycan formation
• heparan sulfate proteoglycan synthesis
• heparan sulphate proteoglycan biosynthesis
• heparan sulphate proteoglycan biosynthetic process
• heparin proteoglycan biosynthetic process

Definition

The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate). 27241222

References

• MetaCyc:PWY-6558
• Reactome:R-HSA-2022928

Ontology

GO: Biological Process    QuickGO    AmiGO