heparan sulfate proteoglycan biosynthetic process

Term ID

GO:0015012

Synonyms

• heparan sulfate proteoglycan anabolism
• heparan sulfate proteoglycan biosynthesis
• heparan sulfate proteoglycan formation
• heparan sulfate proteoglycan synthesis
• heparan sulphate proteoglycan biosynthesis
• heparan sulphate proteoglycan biosynthetic process
• heparin proteoglycan biosynthetic process

Definition

The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. (2)

References

• MetaCyc:PWY-6558
• RESID:AA0210
• Reactome:R-HSA-2022928

Ontology

GO: Biological Process    QuickGO    AmiGO