Search Ontology:
GO: Molecular Function

Rab geranylgeranyltransferase activity

Term ID
GO:0004663
Synonyms
  • geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
  • GGTase-II activity
  • GGTaseII activity
  • protein geranylgeranyltransferase type II activity
  • Rab-protein geranylgeranyltransferase activity
  • RabGGTase activity
  • type II protein geranyl-geranyltransferase activity
Definition
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. (2)
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes
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