CAAX-protein geranylgeranyltransferase activity

Term ID

GO:0004662

Synonyms

• geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
• geranylgeranyltransferase type I activity
• GGTase-I activity
• GGTaseI activity
• protein geranylgeranyltransferase type I
• type I protein geranyl-geranyltransferase activity

Definition

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. (2)

References

• EC:2.5.1.59
• MetaCyc:RXN-3701

Ontology

GO: Molecular Function    QuickGO    AmiGO