calcidiol 1-monooxygenase activity

Term ID

GO:0004498

Synonyms

• 1-hydroxylase-25-hydroxyvitamin D3 activity
• 25-hydroxy D3-1alpha-hydroxylase activity
• 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
• 25-hydroxycholecalciferol 1-hydroxylase activity
• 25-hydroxycholecalciferol 1-monooxygenase activity
• 25-hydroxycholecalciferol 1alpha-hydroxylase activity
• 25-hydroxycholecalciferol-1-hydroxylase activity
• 25-hydroxyvitamin D-1 alpha hydroxylase activity
• 25-hydroxyvitamin D3 1alpha-hydroxylase activity
• 25-OHD-1 alpha-hydroxylase activity
• calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
• cytochrome P450 CYP27B

Definition

Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+. 1.14.15.18

References

• EC:1.14.15.18
• KEGG_REACTION:R03610
• MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
• RHEA:20573
• Reactome:R-HSA-209868
• Reactome:R-HSA-5602186

Ontology

GO: Molecular Function    QuickGO    AmiGO