iodide peroxidase activity

Term ID

GO:0004447

Synonyms

• iodide peroxidase-tyrosine iodinase activity
• iodinase activity
• iodotyrosine deiodase activity
• monoiodotyrosine deiodinase activity
• thyroid peroxidase activity
• thyroperoxidase activity
• TPO activity
• tyrosine iodinase activity

Definition

Catalysis of the reactions: (1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O; (2) [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O; (3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O; (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-dehydroalanine + 2 H2O; (5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O. (2)

References

• EC:1.11.1.8
• MetaCyc:IODIDE-PEROXIDASE-RXN
• RHEA:23336
• RHEA:48956
• RHEA:48960
• RHEA:48964
• RHEA:48968

Ontology

GO: Molecular Function    QuickGO    AmiGO