transcription coactivator activity

Term ID

GO:0003713

Synonyms

• RNA polymerase II transcription co-activator activity
• RNA polymerase II transcription coactivator activity
• RNA polymerase II transcription mediator activity
• transcription co-activator activity

Definition

A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. (2)

References

Ontology

GO: Molecular Function    QuickGO    AmiGO