Factor XII activation

Term ID

GO:0002542

Synonyms

• Hageman factor activation

Definition

Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. 0721601871

References

Ontology

GO: Biological Process    QuickGO    AmiGO