methylation interference footprinting evidence

Term ID

ECO:0001827

Synonyms

• methylation interference footprinting evidence

Definition

A type of nucleic acid binding evidence used to identify protein binding sites on the DNA molecule where multiple copies of a DNA fragment containing a putative TF-binding site are randomly methylated with dimethyl sulfate (DMS) and cleaved at the methyl group, followed by separating the cleavage products on a denaturing electrophoresis gel. 1583685

References

Ontology

Evidence Ontology