core binding factor acute myeloid leukemia

Term ID

DOID:0080796

Synonyms

Definition

An acute myeloid leukemia that is characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis. https://pubmed.ncbi.nlm.nih.gov/26980726/

References

• NCI:C122688

Ontology

Human Disease   ( DOID:0080796 )