early pro-B cell

Term ID

CL:0002046

Synonyms

Definition

A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. 18432934

References

Ontology

Cell Ontology

Relationships

develops into: late pro-B cell

late pro-B cell Show first 5 Terms
is a type of: pro-B cell

pro-B cell Show first 5 Terms
has_low_plasma_membrane_amount: neprilysin

neprilysin Show first 5 Terms
has_plasma_membrane_part: ADP-ribosyl cyclase 1 B-cell receptor CD22 CD34 molecule pre-B cell receptor complex

ADP-ribosyl cyclase 1 B-cell receptor CD22 CD34 molecule pre-B cell receptor complex Show first 5 Terms
lacks_plasma_membrane_part: CD19 molecule complement receptor type 2 membrane-spanning 4-domains subfamily A member 1

CD19 molecule complement receptor type 2 membrane-spanning 4-domains subfamily A member 1 Show first 5 Terms
participates_in: immunoglobulin heavy chain V-D-J recombination

immunoglobulin heavy chain V-D-J recombination Show first 5 Terms