pre-B-I cell

Term ID

CL:0000956

Synonyms

pre-BI cell
pro-B cell (Philadelphia nomenclature)

Definition

A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. (4)

References

Ontology

Cell Ontology

Relationships

develops from: pro-B cell

pro-B cell Show first 5 Terms
is a type of: precursor B cell

precursor B cell Show first 5 Terms
has_part: DNA nucleotidylexotransferase V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2

DNA nucleotidylexotransferase V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2 Show first 5 Terms
has_plasma_membrane_part: CD34 molecule immunoglobulin iota chain immunoglobulin lambda-like polypeptide 1

CD34 molecule immunoglobulin iota chain immunoglobulin lambda-like polypeptide 1 Show first 5 Terms
inverse disjoint_from: pre-B-II cell

pre-B-II cell Show first 5 Terms
participates_in: immunoglobulin heavy chain V-D-J recombination

immunoglobulin heavy chain V-D-J recombination Show first 5 Terms