tramadol

Term ID

CHEBI:9648

Synonyms

(+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
CG-315E
E-265
rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
tramadol
tramadolum
U-26225A

Definition

A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: racemate

racemate Show first 5 Terms
has_part: (R,R)-tramadol (S,S)-tramadol

(R,R)-tramadol (S,S)-tramadol Show first 5 Terms
has_role: adrenergic uptake inhibitor antitussive capsaicin receptor antagonist delta-opioid receptor agonist environmental contaminant ... Show All 14 Terms

adrenergic uptake inhibitor antitussive capsaicin receptor antagonist delta-opioid receptor agonist environmental contaminant kappa-opioid receptor agonist mu-opioid receptor agonist muscarinic antagonist nicotinic antagonist NMDA receptor antagonist opioid analgesic serotonergic antagonist serotonin uptake inhibitor xenobiotic Show first 5 Terms
inverse is_conjugate_acid_of: tramadol(1+)

tramadol(1+) Show first 5 Terms
is_conjugate_base_of: tramadol(1+)

tramadol(1+) Show first 5 Terms

Phenotype

Phenotype resulting from tramadol

Phenotype where environments contain tramadol

Phenotype modified by environments containing tramadol

Human Disease Model