tiagabine

Term ID

CHEBI:9586

Synonyms

• (-)-(R)-1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)nipecotic acid
• (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid
• (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid
• (R)-(-)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid
• (R)-tiagabine
• tiagabina
• tiagabine
• tiagabinum

Definition

A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy.

References

• CAS:115103-54-3
• DrugBank:DB00906
• Drug_Central:2648
• HMDB:HMDB0015042
• KEGG:C07503
• KEGG:D08588
• LINCS:LSM-5700
• PMID:10530690
• PMID:22592677
• PMID:23770680
• PMID:23997364
• PMID:24440890
• PMID:24500879
• PMID:25663257
• PMID:9097364
• PMID:9449883
• Patent:US5010090
• Patent:WO8700171
• Reaxys:6375354
• Wikipedia:Tiagabine

Ontology

ChEBI  ( EBI )

Resources

CTD