tiagabine

Term ID

CHEBI:9586

Synonyms

• (-)-(R)-1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)nipecotic acid
• (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid
• (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid
• (R)-(-)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid
• (R)-tiagabine
• tiagabina
• tiagabine
• tiagabinum

Definition

A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy.

References

• cas:115103-54-3
• drugbank:DB00906
• drugcentral:2648
• hmdb:HMDB0015042
• kegg.compound:C07503
• kegg.drug:D08588
• lincs.smallmolecule:LSM-5700
• patent:US5010090
• patent:WO8700171
• pubmed:10530690
• pubmed:22592677
• pubmed:23770680
• pubmed:23997364
• pubmed:24440890
• pubmed:24500879
• pubmed:25663257
• pubmed:9097364
• pubmed:9449883
• reaxys:6375354
• wikipedia.en:Tiagabine

Ontology

ChEBI  ( EBI )

Resources

CTD