thiamine(1+) diphosphate

Term ID

CHEBI:9532

Synonyms

3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(diphosphooxy)ethyl]-4-methyl-1,3-thiazol-3-ium
ThDP
thiamin diphosphate
thiamine-pyrophosphate
ThPP
TPP

Definition

A thiamine phosphate that is thiamine(1+) in which the hydroxy group has been replaced by a diphosphate group. It is the active form of vitamin B₁ and an essential cofactor for enzymes in key metabolic pathways.

References

cas:136-08-3
chemspider:1100
ecmdb:ECMDB01372
foodb.food:FDB022584
hmdb:HMDB0001372
kegg.compound:C00068
knapsack:C00019627
pdb-ccd:TPP
pubmed:10794754
pubmed:10804457
pubmed:10952481
pubmed:11054793
pubmed:11899071
pubmed:11911339
pubmed:12111441
pubmed:12163191
pubmed:12411483
pubmed:12694175
pubmed:12913150
pubmed:15644336
pubmed:15888311
pubmed:16850348
pubmed:16962976
pubmed:17035501
pubmed:17182735
pubmed:17611796
pubmed:17642321
pubmed:20121944
pubmed:2722424
pubmed:30837347
pubmed:32372067
pubmed:32633484
pubmed:32987117
pubmed:32996449
pubmed:33207817
pubmed:33759569
pubmed:34161071
pubmed:3565758
pubmed:4075519
pubmed:6121420
pubmed:6500839
pubmed:7158773
pubmed:7270482
pubmed:7485819
pubmed:7733128
pubmed:8604141
pubmed:910736
pubmed:9389346
pubmed:9924800
reaxys:3577792
wikipedia.en:Thiamine_pyrophosphate
ymdb:YMDB00381

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from thiamine(1+) diphosphate

Phenotype where environments contain thiamine(1+) diphosphate

Phenotype modified by environments containing thiamine(1+) diphosphate

Phenotype affecting thiamine(1+) diphosphate

Human Disease Model