I-BET151

Term ID

CHEBI:95083

Synonyms

• 7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
• 7-(3,5-dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one
• 7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one
• GSK 1210151A
• GSK-1210151A
• GSK1210151
• GSK1210151A
• I-BET 151

Definition

A member of the class of imidazoquinolines that is 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one substituted by (1R)-1-(pyridin-2-yl)ethyl, 3,5-dimethyl-1,2-oxazol-4-yl, and methoxy groups at positions 1, 7, and 8, respectively. It is a pan-BET bromodomain inhibitor.

References

• cas:1300031-49-5
• lincs.smallmolecule:LSM-6335
• pubmed:22386529
• pubmed:22437115
• pubmed:24335499
• pubmed:24859008
• pubmed:24906137
• pubmed:24924589
• pubmed:25355313
• pubmed:25467295
• pubmed:28983590
• pubmed:29067128
• pubmed:29784003
• pubmed:30061518
• pubmed:30111428
• pubmed:30182276
• pubmed:30300821
• pubmed:30455393
• pubmed:30467325
• pubmed:30518782
• pubmed:30723270
• pubmed:30934680
• pubmed:31206650
• pubmed:32165310
• pubmed:32620617
• pubmed:33664670
• pubmed:34203690
• pubmed:34540687
• pubmed:35196077
• pubmed:35239184
• pubmed:36127412
• pubmed:36230614
• pubmed:36245290
• pubmed:36284375
• pubmed:37097159
• pubmed:37190058
• pubmed:37582225
• pubmed:38152610
• pubmed:38581045

Ontology

ChEBI  ( EBI )