GSK-J4

Term ID

CHEBI:95077

Synonyms

• 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid ethyl ester
• ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate
• ethyl N-[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)pyrimidin-4-yl]-beta-alaninate
• GSK J4
• GSKJ4

Definition

A member of the class of aminopyrimidines that is pyrimidine substituted by pyridin-2-yl, 3-ethoxy-3-oxopropylamino, and 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl groups at positions 2, 4, and 6, respectively. It is an inhibitor of the histone demethylase JMJD3/UTX.

References

• cas:1373423-53-0
• hmdb:HMDB0252948
• lincs.smallmolecule:LSM-6328
• pmc:PMC10670038
• pmc:PMC6217190
• pmc:PMC7651554
• pubmed:22842901
• pubmed:29047260
• pubmed:31241814
• pubmed:31506334
• pubmed:32178714
• pubmed:32393321
• pubmed:32477122
• pubmed:32514253
• pubmed:33446666
• pubmed:35430567
• pubmed:35722096
• pubmed:36012674
• pubmed:36531063
• pubmed:36768182
• pubmed:36792181
• pubmed:36874364
• pubmed:37165737
• pubmed:37330650
• pubmed:37566089
• pubmed:38001607
• pubmed:38317193
• pubmed:38393716
• pubmed:38499211
• pubmed:39036915
• pubmed:39307916
• pubmed:39482699
• pubmed:39577709
• pubmed:39791538
• pubmed:39813767

Ontology

ChEBI  ( EBI )