UNC0638

Term ID

CHEBI:95074

Synonyms

• 2-cyclohexyl-6-methoxy-N-(1-propan-2-yl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
• 2-cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
• 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamin
• 2-cyclohexyl-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
• 2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy) quinazolin-4-amine
• UNC 0638
• UNC-0638

Definition

A member of the class of quinazolines that is quinazoline substituted by cyclohexyl, [1-(propan-2-yl)piperidin-4-yl]amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It inhibits G9a and GLP histone methyltransferase activity (IC₅₀ = <15 nM and <20 nM, respectively).

References

• cas:1255580-76-7
• lincs.smallmolecule:LSM-6325
• pdb-ccd:CIQ
• pubmed:21743462
• pubmed:21769094
• pubmed:24467723
• pubmed:27252354
• pubmed:28246360
• pubmed:29207160
• pubmed:31260300
• pubmed:32567028
• pubmed:32608992
• pubmed:32661262
• pubmed:32729861
• pubmed:32774698
• pubmed:32956454
• pubmed:33054052
• pubmed:33099471
• pubmed:34336110
• pubmed:34798471
• pubmed:36150523
• pubmed:38277395
• pubmed:38533580
• pubmed:39160629
• pubmed:39740997
• pubmed:39824634

Ontology

ChEBI  ( EBI )