dinaciclib

Term ID

CHEBI:95060

Synonyms

(2S)-1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
2-[(2S)-1-(3-ethyl-7-{[(1-oxidopyridin-3-yl)methyl]amino}pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-2-yl]ethanol
2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
dinaciclib
dinaciclibum
MK 7965
MK-7965
MK7965
SCH 727965
SCH-727965
SCH727965

Definition

A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine substituted by ethyl, (2S)-2-(2-hydroxyethyl)piperidin-1-yl, and [(1-oxidopyridin-3-yl)methyl]amino groups at positions 3, 5, and 7, respectively. It is a potent pan-cyclin dependent kinase inhibitor that exhibits antineoplastic activity.

References

cas:779353-01-4
drugbank:DB12021
kegg.drug:D09604
lincs.smallmolecule:LSM-6306
pdb-ccd:1QK
pubmed:20663931
pubmed:21490307
pubmed:22315240
pubmed:23949430
pubmed:24007471
pubmed:24388167
pubmed:24393852
pubmed:24568369
pubmed:24900195
pubmed:25947565
pubmed:26018905
pubmed:27496135
pubmed:30472117
pubmed:31207099
pubmed:32269732
pubmed:32944844
pubmed:34972202
pubmed:35170591
pubmed:35884614
pubmed:36505806
pubmed:36586018
pubmed:36700399
pubmed:36979907
pubmed:37104883
pubmed:37270540
pubmed:37694833
pubmed:37703185
pubmed:37704591
pubmed:38135130
pubmed:38254859
pubmed:38438856
pubmed:38474332
pubmed:38480681
pubmed:38545471
pubmed:38685605
pubmed:38786326
pubmed:38845263
wikipedia.en:Dinaciclib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from dinaciclib

Phenotype where environments contain dinaciclib

Phenotype modified by environments containing dinaciclib

Phenotype affecting dinaciclib

Human Disease Model