orlistat

Term ID

CHEBI:94686

Synonyms

• (-)-tetrahydrolipostatin
• (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl N-formyl-L-leucinate
• (2S)-2-formamido-4-methylpentanoic acid [(2S)-1-[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]tridecan-2-yl] ester
• Alli
• N-formyl-L-leucine (1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl}dodecyl ester
• orlipastat
• orlistat
• orlistatum
• Ro-18-0647
• Xenical

Definition

A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.

References

• cas:96829-58-2
• drugcentral:1996
• kegg.drug:D04028
• lincs.smallmolecule:LSM-5724
• patent:EP129748
• patent:US4598089
• pubmed:27793869
• pubmed:28097013
• pubmed:28191026
• pubmed:28260907
• pubmed:28387458
• pubmed:28559211
• pubmed:28588183
• pubmed:28624425
• reaxys:3658031
• wikipedia.en:Orlistat

Ontology

ChEBI  ( EBI )

Resources

CTD