tetrabenazine

Term ID

CHEBI:9467

Synonyms

• 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one
• 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one
• 2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine
• Nitoman
• rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• Ro 1-9569
• TBZ
• tetrabenazina
• Tetrabenazine
• tetrabenazinum
• Xenazine

Definition

A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia.

References

• CAS:58-46-8
• DrugBank:DB04844
• KEGG:C11168
• KEGG:D08575
• PMID:10686169
• PMID:19929707
• PMID:20442355
• PMID:20869622
• PMID:21487088
• PMID:9040721
• Patent:US2830993
• Reaxys:9356999
• Wikipedia:Tetrabenazine

Ontology

ChEBI  ( EBI )

Resources

CTD