L-buthionine-(S,R)-sulfoximine

Term ID

CHEBI:94288

Synonyms

(2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid
(2S)-2-amino-4-(S-butylsulfonimidoyl)butanoic acid
(2S)-2-amino-4-(S-butylsulfonimidoyl)butyric acid
L-BSO
L-buthionine (SR)-sulfoximine
L-buthionine sulfoximine
L-buthionine-(S,R)-sulfoximine
L-buthionine-(S,R)-sulphoximine

Definition

A 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of γ-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents.

References

cas:83730-53-4
chemspider:106767
lincs.smallmolecule:LSM-4915
pubmed:12184532
pubmed:15960602
pubmed:18587629
pubmed:19167492
pubmed:21172425
pubmed:24912031
pubmed:25921122
pubmed:26153194
pubmed:30325050
pubmed:31461931
pubmed:31766654
pubmed:32028640
pubmed:32146577
pubmed:32575563
pubmed:32617545
pubmed:32639526
pubmed:32788523
pubmed:32812608
pubmed:33198939
pubmed:33303231
pubmed:9467825
pubmed:9504394
reaxys:2367136

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from L-buthionine-(S,R)-sulfoximine

Phenotype where environments contain L-buthionine-(S,R)-sulfoximine

Phenotype modified by environments containing L-buthionine-(S,R)-sulfoximine

Phenotype affecting L-buthionine-(S,R)-sulfoximine

Human Disease Model