erastin

Term ID

CHEBI:94287

Synonyms

2-(1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

Definition

A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.

References

cas:571203-78-6
chemspider:9390002
kegg.compound:C21478
lincs.smallmolecule:LSM-4914
pubmed:12676586
pubmed:17568748
pubmed:22832321
pubmed:26231156
pubmed:30522056
pubmed:31273299
pubmed:31464035
pubmed:31921655
pubmed:31974380
pubmed:31997820
pubmed:32089268
pubmed:32209255
pubmed:32606760
pubmed:32608563
pubmed:32642794
pubmed:32793311
pubmed:32893325
pubmed:32945484
pubmed:32979793
pubmed:33245979
pubmed:33333051
pubmed:33378529
pubmed:33609745
pubmed:33649848
pubmed:33675143
pubmed:33681481
pubmed:33864570
pubmed:33882617
pubmed:34012798
wikipedia.en:Erastin

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from erastin

Phenotype where environments contain erastin

Phenotype modified by environments containing erastin

Phenotype affecting erastin

Human Disease Model