givinostat

Term ID

CHEBI:94187

Synonyms

(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate
[6-[(diethylamino)methyl]naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
gavinostat
givinostat
givinostatum
ITF 2357
ITF-2357
ITF2357
{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate

Definition

A member of the class of naphthalenes that is naphthalene substituted by ({[4-(hydroxycarbamoyl)phenyl]carbamoyl}oxy)methyl and (diethylamino)methyl groups at positions 2 and 6, respectively. It is a histone deacetylase inhibitor indicated for individuals diagnosed with Duchenne muscular dystrophy.

References

cas:497833-27-9
drugbank:DB12645
hmdb:HMDB0252732
kegg.drug:D12742
lincs.smallmolecule:LSM-4807
pdb-ccd:QCM
pubmed:20560970
pubmed:22781793
pubmed:27833530
pubmed:30474756
pubmed:31346710
pubmed:31755702
pubmed:32693648
pubmed:33682427
pubmed:34136349
pubmed:34197911
pubmed:34341511
pubmed:35571097
pubmed:35740641
pubmed:35894303
pubmed:35955430
pubmed:36009541
pubmed:36108615
pubmed:36397155
pubmed:36445551
pubmed:36793108
pubmed:36793492
pubmed:36854532
pubmed:37298104
pubmed:37306105
pubmed:37841928
pubmed:38316447
pubmed:38327117
pubmed:38430220
pubmed:38508835
wikipedia.en:Givinostat

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from givinostat

Phenotype where environments contain givinostat

Phenotype modified by environments containing givinostat

Phenotype affecting givinostat

Human Disease Model