PF-3758309

Term ID

CHEBI:93751

Synonyms

• N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
• PF 309
• PF 3758309
• PF-03758309
• PF-309
• PF309
• PF3758309

Definition

A member of the class of thienopyrimidines that is thieno[3,2-d]pyrimidine substituted by methyl and (5-{[(1S)-2-(dimethylamino)-1-phenylethyl]carbamoyl}-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)amino groups at positions 2 and 4, respectively. It is a potent inhibitor of PAK4 and inhibits the growth of multiple human tumor xenografts.

References

• cas:898044-15-0
• drugbank:DB11775
• lincs.smallmolecule:LSM-4254
• pdb-ccd:7KC
• pubmed:20439741
• pubmed:23524533
• pubmed:23543898
• pubmed:24204982
• pubmed:24366569
• pubmed:24432870
• pubmed:25640698
• pubmed:29048629
• pubmed:29191878
• pubmed:30455231
• pubmed:31312349
• pubmed:31595158
• pubmed:32469945
• pubmed:32829006
• pubmed:33414491
• pubmed:33987822
• pubmed:35401439
• pubmed:35939342
• pubmed:36240067
• pubmed:36671485
• pubmed:37258566
• pubmed:37564209
• pubmed:37568037
• pubmed:37864885
• pubmed:38336988
• pubmed:38885414

Ontology

ChEBI  ( EBI )