sulindac

Term ID

CHEBI:9352

Synonyms

• (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
• cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
• cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
• Clinoril
• Sulindac
• sulindaco
• Sulindacum
• {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

Definition

A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

References

• cas:38194-50-2
• drugbank:DB00605
• drugcentral:2534
• hmdb:HMDB0014743
• kegg.compound:C01531
• kegg.drug:D00120
• patent:DE2039426
• patent:US3654349
• pdb-ccd:SUZ
• pubmed:11569947
• pubmed:11927004
• pubmed:12406542
• pubmed:15020200
• pubmed:15123337
• pubmed:19884509
• pubmed:23689354
• pubmed:23804703
• reaxys:2951842
• wikipedia.en:Sulindac

Ontology

ChEBI  ( EBI )

Resources

CTD