SB225002

Term ID

CHEBI:93074

Synonyms

1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea
PD 157695
PD-157695
PD157695
SB 225002
SB-225002

Definition

A member of the class of phenylureas that is urea in which one of the amino groups is substituted by a (2-bromophenyl)amino group while the other is substituted by a (2-hydroxy-4-nitrophenyl)amino group. It is a potent CXCR2 chemokine receptor antagonist (IC₅₀ = 22 nM).

References

cas:182498-32-4
lincs.smallmolecule:LSM-3367
pubmed:12628493
pubmed:18653784
pubmed:19264522
pubmed:20021889
pubmed:23359652
pubmed:23611835
pubmed:26302043
pubmed:29765453
pubmed:29917166
pubmed:30829852
pubmed:31494226
pubmed:31927212
pubmed:32119843
pubmed:32616311
pubmed:32639881
pubmed:32736336
pubmed:33517283
pubmed:33773907
pubmed:33785307
pubmed:34146540
pubmed:35264061
pubmed:35647855
pubmed:35856448
pubmed:36614059
pubmed:36872429
pubmed:37063917
pubmed:37481938
pubmed:37824136
pubmed:38493581
pubmed:38501672
pubmed:38704076
reaxys:10689013

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from SB225002

Phenotype where environments contain SB225002

Phenotype modified by environments containing SB225002

Phenotype affecting SB225002

Human Disease Model