Search Ontology:
ChEBI
Ro 25-6981
- Term ID
- CHEBI:92897
- Synonyms
-
- (alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol
- 4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
- 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
- Ro 25-6981 free base
- Ro-25-6981
- Ro25-6981
- Definition
- A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.
- References
-
- CAS:169274-78-6
- Chemspider:5037146
- LINCS:LSM-3140
- PDBeChem:QEM
- PMID:11290368
- PMID:12498913
- PMID:14534359
- PMID:15081591
- PMID:15256539
- PMID:17970830
- PMID:18809426
- PMID:21598675
- PMID:21677647
- PMID:23113280
- PMID:24076088
- PMID:24893066
- PMID:25008524
- PMID:25446739
- PMID:27062927
- PMID:27456026
- PMID:27871866
- PMID:28802646
- PMID:29777135
- PMID:29790100
- PMID:29800545
- PMID:29862605
- PMID:32640759
- PMID:32925228
- PMID:34363521
- PMID:34453973
- PMID:34575558
- PMID:9400004
- PMID:9572302
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
- inverse is_conjugate_acid_of
-
- is_conjugate_base_of
-
Show first 5 Terms
Phenotype
Phenotype resulting from Ro 25-6981
Phenotype where environments contain Ro 25-6981
Phenotype modified by environments containing Ro 25-6981
Human Disease Model