Search Ontology:
ChEBI
PD158780
- Term ID
- CHEBI:92843
- Synonyms
-
- 4-(3-bromoanilino)-6-(methylamino)pyrido[3,4-d]pyrimidine
- 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine
- 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine
- N(4)-(3-bromophenyl)-N(6)-methylpyrido[3,4-d]pyrimidine-4,6-diamine
- PD 158780
- PD-158780
- Definition
- A pyridopyrimidine that is pyrido[3,4-d]pyrimidine-4,6-diamine in which the amino groups at positions 4 and 6 are substituted by a m-bromophenyl group and a methyl group, respectively. It is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity [IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4)]. It does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
- References
-
- cas:171179-06-9
- lincs.smallmolecule:LSM-3069
- pubmed:10368634
- pubmed:12548551
- pubmed:15572027
- pubmed:17079657
- pubmed:22354538
- pubmed:27988307
- pubmed:9354588
- pubmed:9513602
- pubmed:9603960
- reaxys:7487408
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from PD158780
Phenotype where environments contain PD158780
Phenotype modified by environments containing PD158780
Phenotype affecting PD158780
Human Disease Model