SL-327

Term ID

CHEBI:92211

Synonyms

• 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile
• 3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile
• alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile
• SL 327
• SL327

Definition

A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.

References

• cas:305350-87-2
• lincs.smallmolecule:LSM-2253
• pubmed:10969080
• pubmed:12490588
• pubmed:18766328
• pubmed:21074569
• pubmed:21312031
• reaxys:9423720

Ontology

ChEBI  ( EBI )