simvastatin

Term ID

CHEBI:9150

Synonyms

• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
• MK-733
• simvastatin
• Simvastatina
• Simvastatine
• Simvastatinum
• Zocor

Definition

A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.

References

• beilstein:4768037
• cas:79902-63-9
• drugbank:DB00641
• drugcentral:2445
• hmdb:HMDB0005007
• kegg.drug:D00434
• lincs.smallmolecule:LSM-2492
• patent:EP33538
• patent:US4444784
• pubmed:11336576
• pubmed:12827636
• pubmed:14561068
• pubmed:14691614
• pubmed:14973129
• pubmed:16144183
• pubmed:17640385
• pubmed:18199328
• pubmed:18688862
• pubmed:18936176
• pubmed:22737247
• wikipedia.en:Simvastatin

Ontology

ChEBI  ( EBI )

Resources

CTD