Search Ontology:
ChEBI
CHIR-265
- Term ID
- CHEBI:91451
- Synonyms
-
- 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
- CHIR 265
- CHIR265
- RAF 265
- RAF-265
- RAF265
- Definition
- A member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant.
- References
-
- CAS:927880-90-8
- LINCS:LSM-1207
- PDBeChem:55J
- PMID:20124452
- PMID:20356670
- PMID:21317202
- PMID:21390189
- PMID:21527556
- PMID:21667024
- PMID:21831957
- PMID:22121538
- PMID:22319199
- PMID:22351689
- PMID:22773056
- PMID:24821574
- PMID:24864047
- PMID:25884645
- PMID:26081844
- PMID:26396681
- PMID:28719152
- PMID:29934490
- PMID:29986755
- PMID:36251738
- PMID:36298816
- PMID:36447653
- Patent:WO2011044072
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
- has_role
Phenotype
Phenotype resulting from CHIR-265
Phenotype where environments contain CHIR-265
Phenotype modified by environments containing CHIR-265
Human Disease / Model Data
Citations