CHIR-265

Term ID

CHEBI:91451

Synonyms

• 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
• CHIR 265
• CHIR265
• RAF 265
• RAF-265
• RAF265

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant.

References

• CAS:927880-90-8
• LINCS:LSM-1207
• PDBeChem:55J
• PMID:20124452
• PMID:20356670
• PMID:21317202
• PMID:21390189
• PMID:21527556
• PMID:21667024
• PMID:21831957
• PMID:22121538
• PMID:22319199
• PMID:22351689
• PMID:22773056
• PMID:24821574
• PMID:24864047
• PMID:25884645
• PMID:26081844
• PMID:26396681
• PMID:28719152
• PMID:29934490
• PMID:29986755
• PMID:36251738
• PMID:36298816
• PMID:36447653
• Patent:WO2011044072

Ontology

ChEBI  ( EBI )

Resources

CTD