PF-573228

Term ID

CHEBI:91446

Synonyms

3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
6-[(4-((3-(methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one
6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one
6-{[4-{[3-(methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3,4-dihydroquinolin-2(1H)-one
PF 228
PF 573,228
PF 573228
PF-228
PF-573,228
PF573,228
PF573228

(all 11)

Definition

A quinolone that is 3,4-dihydroquinolin-2(1H)-one substituted by a [4-{[3-(methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino group at position 6. It is a potent inhibitor of focal adhesion kinase (IC50 = 4 nM).

References

(all 21)

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyrimidine benzenes organofluorine compound quinolone secondary amino compound ... Show All 6 Terms

aminopyrimidine benzenes organofluorine compound quinolone secondary amino compound sulfone Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor

angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from PF-573228

Phenotype where environments contain PF-573228

Phenotype modified by environments containing PF-573228

Phenotype affecting PF-573228

Human Disease Model