Search Ontology:
ChEBI
PF-573228
- Term ID
- CHEBI:91446
- Synonyms
-
- 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
- 6-[(4-((3-(methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one
- 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one
- 6-{[4-{[3-(methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3,4-dihydroquinolin-2(1H)-one
- PF 228
- PF 573,228
- PF 573228
- PF-228
- PF-573,228
- PF573,228
- PF573228
- Definition
- A quinolone that is 3,4-dihydroquinolin-2(1H)-one substituted by a [4-{[3-(methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino group at position 6. It is a potent inhibitor of focal adhesion kinase (IC50 = 4 nM).
- References
-
- cas:869288-64-2
- hmdb:HMDB0247536
- lincs.smallmolecule:LSM-1200
- pdb-ccd:P4N
- pubmed:17395594
- pubmed:21925512
- pubmed:27383888
- pubmed:28459212
- pubmed:29190494
- pubmed:29303405
- pubmed:29633338
- pubmed:29969688
- pubmed:30352800
- pubmed:30761269
- pubmed:30807921
- pubmed:33497606
- pubmed:36497072
- pubmed:37236435
- pubmed:38050825
- pubmed:38116014
- pubmed:38638133
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from PF-573228
Phenotype where environments contain PF-573228
Phenotype modified by environments containing PF-573228
Phenotype affecting PF-573228
Human Disease Model