adavosertib

Term ID

CHEBI:91414

Synonyms

1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
adavosertib
adavosertibum
AZD 1775
AZD-1775
AZD1775
MK 1775
MK-1775
MK1775

Definition

A member of the class of pyrazolopyrimidines that is 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one substituted by 6-(2-hydroxypropan-2-yl)pyridin-2-yl, prop-1-en-3-yl, [4-(4-methylpiperazin-1-yl)phenyl]amino groups at positions 1, 2, and 6, respectively. It is a potent and selective oral inhibitor of WEE1 kinase.

References

cas:955365-80-7
drugbank:DB11740
hmdb:HMDB0254782
kegg.drug:D11361
lincs.smallmolecule:LSM-1153
pdb-ccd:8X7
pmc:PMC11183722
pubmed:19887545
pubmed:28792760
pubmed:31540690
pubmed:32556602
pubmed:33670166
pubmed:33863809
pubmed:34212455
pubmed:34379792
pubmed:34538072
pubmed:35672254
pubmed:36524815
pubmed:36612094
pubmed:37081608
pubmed:37197456
pubmed:37278879
pubmed:37279095
pubmed:37296592
pubmed:37368100
pubmed:37370065
pubmed:37380217
pubmed:37394627
pubmed:37426130
pubmed:37633054
pubmed:37659202
pubmed:37715172
pubmed:37758718
pubmed:38051741
pubmed:38085423
pubmed:38103761
pubmed:38167245
pubmed:38519399
pubmed:38593512
pubmed:38920407
wikipedia.en:Adavosertib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from adavosertib

Phenotype where environments contain adavosertib

Phenotype modified by environments containing adavosertib

Phenotype affecting adavosertib

Human Disease Model